Genevieve has a few tips about what to do if urine gets into the container while collecting your stool sample. Do not use if you have had adenomas, have inflammatory bowel disease, certain hereditary syndromes, or a personal or family history of colorectal cancer. Cologuard is not a replacement for colonoscopy in high risk patients. Cologuard performance in adults ages 45-49 is estimated based on a large clinical study of patients 50 and older. False positives and false negatives can occur. Rx o